Small Molecule GS-Nitroxide Radiation Mitigator JP4-039/F14 Is Safe and Effective in Pregnant E13.5 Mice
نویسندگان
چکیده
منابع مشابه
Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria.
JP4-039 is a lead structure in a series of nitroxide conjugates that are capable of accumulating in mitochondria and scavenging reactive oxygen species (ROS). To explore structure-activity relationships (SAR), new analogs with variable nitroxide moieties were prepared. Furthermore, fluorophore-tagged analogs were synthesized and provided the opportunity for visualization in mitochondria. All an...
متن کاملIntraesophageal administration of GS-nitroxide (JP4-039) protects against ionizing irradiation-induced esophagitis.
BACKGROUND/AIM this study evaluated esophageal radioprotection by the Gramicidin S (GS) derived-nitroxide, JP4-039, a mitochondrial targeting peptide-isostere covalently-linked to 4-amino-Tempo, delivered in a novel swallowed oil-based (F15) formulation. MATERIALS AND METHODS C57BL/6HNsd female mice received intraesophageal F15 formulation containing JP4-039 (4 mg/ml in 100 microl volumes) 10...
متن کاملSmall molecule GS-nitroxide ameliorates ionizing irradiation-induced delay in bone wound healing in a novel murine model.
We studied radioprotection and mitigation by mitochondrial-targeted Tempol (GS-nitroxide, JP4-039), in a mouse injury/irradiation model of combined injury (fracture/irradiation). Right hind legs of control C57BL/6NHsd female mice, mice pretreated with MnSOD-PL, JP4-039, or with amifostine were irradiated with single and fractionated doses of 0 to 20 Gy. Twenty-four hours later, unicortical hole...
متن کاملIs Safe and Effective
18 This issue marks the beginning of a new section of the Journal, the “Bioethics and Law Forum.” As its first editor. I am pleased to see the level of interest in ethical and legal issues related to issues in infertility and can predict that there will be no shortage of interesting and provocative questions addressed in the “Forum” in the upcoming months. The articles appearing this month are ...
متن کاملEsophageal radioprotection by swallowed JP4-039/F15 in thoracic-irradiated mice with transgenic lung tumors.
BACKGROUND/AIM To determine whether Gramicidin S (GS)-nitroxide, JP4-039, esophageal radiation protection protected lung tumors in a transgenic model, LoxP-Stoop-LoxP Kristen Rat Sarcoma Viral oncogene (LSL-K-RAS) mice were administered intra-tracheal- Carbapenem-resistant Enterobacteriaceae (CRE) recombinase, bilateral lung tumors were confirmed at 11 weeks, then thoracic irradiation was deliv...
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ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2016
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2016.06.2050